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The molecular basis of neutral aminoacidurias

Angelika Bröer1, Juleen A Cavanaugh, John E J Rasko

  • 1School of Biochemistry and Molecular Biology, Australian National University, Canberra.

Pflugers Archiv : European Journal of Physiology
|July 30, 2005
PubMed

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Basicity of Heterocyclic Aromatic Amines

Heterocyclic amines, where the N atom is a part of an alicyclic system, are similar in basicity to alkylamines. Interestingly, the heterocyclic amine having a nitrogen atom as part of an aromatic ring has much less basicity than its corresponding alicyclic counterpart. For this reason, as presented in Figure 1, piperidine (pKb = 2.8) is significantly more basic than pyridine (pKb = 8.8).
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