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Nephroblastomatosis and nephroblastoma in nonhuman primates
S Denise Goens1, Charleen M Moore, Kathleen M Brasky
1Department of Comparative Medicine, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA.
Journal of Medical Primatology
|August 2, 2005
Summary
This study reports the first cases of Wilms tumors (nephroblastomas) in baboons and a related condition in cynomolgus macaques. These nonhuman primate kidney tumors resemble human Wilms tumors but lack associated genetic markers.
Area of Science:
- Comparative Pathology
- Oncology
- Primate Medicine
Background:
- Wilms tumors (nephroblastomas) are common human kidney cancers.
- Nephroblastomas are rare in nonhuman primates, making their study crucial for comparative oncology.
Observation:
- Three cases of spontaneous renal tumors in young monkeys are detailed: two baboons with unilateral nephroblastomas and one cynomolgus macaque with nephroblastomatosis.
- Histological examination revealed baboon tumors were typical of human Wilms tumors, while the macaque tumor showed a diffuse pattern consistent with nephroblastomatosis.
Findings:
- Cytogenetic analysis found no chromosomal abnormalities analogous to human Wilms tumors in the macaque or baboon tumors.
- The macaque tumor's diffuse nature allowed for the first reported differentiation of nephroblastomatosis from nephroblastoma in a nonhuman primate species.
Implications:
- These findings suggest nonhuman primate nephroblastomas and nephroblastomatosis develop similarly to human Wilms tumors.
- Further research into nonhuman primate models may offer insights into Wilms tumor pathogenesis and treatment, despite the absence of known genetic markers.