Related Experiment Video
Updated: Aug 16, 2026

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
Published on: March 19, 2019
Manganese superoxide dismutase in pathogenic fungi: an issue with pathophysiological and phylogenetic involvements
Emilie Fréalle1, Christophe Noël, Eric Viscogliosi
1ECOPA (EA 3609), Lille Pasteur Institute, France. emilie.frealle@pasteur-lille.fr
Abstract:
Manganese-containing superoxide dismutases (MnSODs) are ubiquitous metalloenzymes involved in cell defence against endogenous and exogenous reactive oxygen species. In fungi, using this essential enzyme for phylogenetic analysis of Pneumocystis and Ganoderma genera, and of species selected among Ascomycota, Basidiomycota and Zygomycota, provided interesting results in taxonomy and evolution. The role of mitochondrial and cytosolic MnSODs was explored in some pathogenic Basidiomycota yeasts (Cryptococcus neoformans var. grubii, Cryptococcus neoformans var. gattii, Malassezia sympodialis), Ascomycota filamentous fungi (Aspergillus fumigatus), and Ascomycota yeasts (Candida albicans). MnSOD-based phylogenetic and pathogenic data are confronted in order to evaluate the roles of fungal MnSODs in pathophysiological mechanisms.
Related Concept Videos
Fungal Group Zygomycota
Fungal Phylum Microsporidia
Microbes and Other Elemental Cycles
Fungal Phylum Basidiomycota
Fungal Phylum Ascomycota
Antifungal Agents
