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Serum IL-2 in chronic hepatitis B virus infected patients and its association with disease activity

C R Debnath1, K Alam, C B Sarker

  • 1Medicine unit-I, Mymensingh Medical College Hospital, Mymensingh, Bangladesh. chitta_dr@yahoo.com

Mymensingh Medical Journal : MMJ
|August 2, 2005
PubMed

Insights

Serum Interleukin-2 (IL-2) levels are significantly elevated in active chronic hepatitis B (CHB) patients. This finding suggests IL-2 can serve as a valuable biomarker for CHB activity.

Area of Science:

  • Hepatology
  • Immunology
  • Virology

Background:

  • Chronic hepatitis B (CHB) is a significant global health concern.
  • Assessing CHB activity is crucial for effective patient management.
  • Interleukin-2 (IL-2) is a cytokine involved in immune responses.

Purpose of the Study:

  • To evaluate the association between serum Interleukin-2 (IL-2) levels and the activity of chronic hepatitis B (CHB).
  • To determine if IL-2 can serve as a biomarker for CHB disease activity.

Main Methods:

  • A study involving 45 subjects divided into three groups: active CHB patients (Group A), CHB carriers with normal ALT (Group B), and healthy controls (Group C).
  • Serum IL-2 levels were measured in all groups.
  • Statistical analysis (Z-test) was employed to compare IL-2 levels between groups.

Main Results:

  • Serum IL-2 was detected in 93.33% of active CHB patients (Group A) and 13.33% of CHB carriers (Group B).
  • IL-2 was undetectable in all healthy subjects (Group C).
  • A statistically significant difference in IL-2 levels was observed between Group A and Group B (p<0.001), and between Group A and Group C (p<0.001). No significant difference was found between Group B and Group C (p>0.05).

Conclusions:

  • Serum IL-2 levels are significantly associated with the activity of chronic hepatitis B.
  • IL-2 demonstrates potential as a reliable biomarker for identifying active CHB infection.
  • Further research may validate IL-2's role in CHB management strategies.

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