Related Experiment Video

Updated: Aug 16, 2026

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry
08:07

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry

Published on: July 26, 2019

Regulation of gene-activation pathways by PIAS proteins in the immune system

Ke Shuai1, Bin Liu

  • 1Division of Hematology-Oncology, Department of Medicine, University of California, Los Angeles, California 90095, USA. kshuai@mednet.ucla.edu

Nature Reviews. Immunology
|August 2, 2005
PubMed

Insights

Protein inhibitors of activated STAT (PIAS) regulate key transcription factors and innate immune responses. This review details their molecular mechanisms and physiological roles in immune gene activation.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • The protein inhibitor of activated STAT (PIAS) family regulates diverse transcription factors, including STATs, NF-kappaB, SMADs, and p53.
  • PIAS proteins modulate gene transcription via DNA-binding interference, recruitment of co-regulators, and promotion of sumoylation.
  • Emerging genetic evidence highlights PIAS proteins' critical role in vivo within innate immune responses.

Purpose of the Study:

  • To review the current understanding of PIAS protein function in the immune system.
  • To elucidate the molecular basis, specificity, and physiological roles of PIAS proteins in regulating gene activation pathways.

Main Methods:

  • Literature review of genetic studies and molecular mechanisms.
  • Analysis of PIAS protein interactions with transcription factors.
  • Examination of PIAS roles in innate immunity.

Main Results:

  • PIAS proteins are crucial regulators of transcription factor activity.
  • Multiple mechanisms employed by PIAS proteins control gene expression.
  • In vivo studies confirm PIAS involvement in innate immune regulation.

Conclusions:

  • PIAS proteins are essential for modulating immune responses through intricate molecular mechanisms.
  • Further research into PIAS proteins offers insights into immune system regulation and potential therapeutic targets.

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