[Left ventricular hypertrophy in paediatric predialysis children and treatment--induced regression of left

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Dagmara Borzych1, Aleksandra Zurowska, Irena Bałasz

  • 1Z Kliniki Nefrologii Dzieciecej, Akademii Medycznej w Gdańsku. dagab@amg.gda.pl

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|August 3, 2005
PubMed

Insights

Left ventricular hypertrophy (LVH) is common in children with chronic renal failure (CRF). Effective antihypertensive treatment can significantly reduce left ventricular mass in these young patients.

Area of Science:

  • Pediatric Nephrology
  • Cardiology
  • Cardiovascular Research

Background:

  • Cardiovascular disease is a leading cause of death in adults with chronic renal failure (CRF).
  • Paediatric CRF patients are also at high risk for cardiovascular complications.
  • Early detection of cardiovascular disease predictors in chronic renal insufficiency is crucial.

Purpose of the Study:

  • To analyze the prevalence of left ventricular hypertrophy (LVH) in predialysis paediatric CRF patients.
  • To assess the potential of antihypertensive treatment in regressing left ventricular mass.

Main Methods:

  • Echocardiographic evaluations were performed on 49 CRF patients (aged 2-19 years) at diagnosis and after 30 months of antihypertensive treatment.
  • LVH was defined as a left ventricular mass index (LVMI) greater than 51 g/m2.7.
  • Antihypertensive treatment efficacy was evaluated based on changes in LVMI.

Main Results:

  • LVH was prevalent in 63.2% (18/49) of children at baseline CRF diagnosis.
  • After 30 months of antihypertensive treatment, LVH was present in only 14.2% (7/49) of the children.
  • A significant reduction in left ventricular mass was observed.

Conclusions:

  • Left ventricular hypertrophy is a common finding in young patients with chronic renal failure.
  • Effective antihypertensive treatment can lead to the regression of left ventricular mass in this population.
Abstract

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