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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Flavonoid composition and antimicrobial activity of Cirsium rivulare (Jacq.) All. flowers
Jolanta Nazaruk1, Piotr Jakoniuk
1Department of Pharmacognosy, Medical University of Białystok, Mickiewicza 2a Street, Białystok 15-089, Poland. nazaruk@amb.edu.pl
Abstract:
A new flavonoid compound isokaempferide 7-O-beta-d-(6''-methylglucuronide) (1) was isolated from flowers of Cirsium rivulare (Jacq.) All. Its structure was elucidated on the basis of spectroscopic studies (UV, (1)H and (13)C NMR, FABMS). Moreover, five known flavonoid compounds: apigenin 7-(6''-methylglucuronide) (2), hispidulin 7-glucoside (3), isokaempferide 7-glucuronide (4), kaempferol 3-galactoside (5), pectolinarin (6) were isolated from this source for the first time. The antimicrobial activity of aqueous, methanolic and 70% ethanolic extracts of Cirsium rivulare flowers and leaves was also evaluated.
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