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Updated: Aug 7, 2026
10:24
Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry
Published on: October 28, 2014
Effect of hydrochlorothiazide on renal hypercalciuria
I Voskaki1, A al Qadreh, C Mengreli
1Institute of Child Health, Aghia Sophia Children's Hospital, Athens, Greece.
Child Nephrology and Urology
|January 1, 1992
Summary
Hydrochlorothiazide (HCT) effectively treats renal hypercalciuria in children, reducing urinary calcium and preventing kidney stones. This long-term study found no adverse effects, showing significant improvements in bone mineral content.
Area of Science:
- Pediatric Nephrology
- Pharmacology
Background:
- Renal hypercalciuria (HCU) is a condition characterized by excessive calcium excretion in the urine.
- Long-term management strategies for pediatric HCU are crucial for preventing kidney stone formation and preserving bone health.
Purpose of the Study:
- To evaluate the long-term efficacy and safety of hydrochlorothiazide (HCT) in pediatric patients with renal hypercalciuria.
- To assess the impact of HCT on renal calcium excretion, serum biochemistry, and bone mineral content.
Main Methods:
- A cohort of 30 children (aged 4-13 years) with HCU received 1 mg/kg/day of HCT for an average of 2.5 years.
- Comprehensive monitoring included urinary calcium, serum electrolytes, parathyroid hormone, nephrogenic cAMP, and bone mineral content.
Main Results:
- HCT demonstrated rapid and sustained correction of HCU.
- Significant increases in bone mineral content and reductions in serum cPTH and ncAMP were observed.
- The treatment effectively prevented new stone formation or growth of existing stones, with no reported side effects.
Conclusions:
- Hydrochlorothiazide is a safe and effective long-term treatment for renal hypercalciuria in children.
- HCT improves bone mineral density and reduces the risk of kidney stone recurrence in this pediatric population.
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