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Effect of hydrochlorothiazide on renal hypercalciuria

I Voskaki1, A al Qadreh, C Mengreli

  • 1Institute of Child Health, Aghia Sophia Children's Hospital, Athens, Greece.

Child Nephrology and Urology
|January 1, 1992
PubMed

Insights

Hydrochlorothiazide (HCT) effectively treats renal hypercalciuria in children, reducing urinary calcium and preventing kidney stones. This long-term study found no adverse effects, showing significant improvements in bone mineral content.

Area of Science:

  • Pediatric Nephrology
  • Pharmacology

Background:

  • Renal hypercalciuria (HCU) is a condition characterized by excessive calcium excretion in the urine.
  • Long-term management strategies for pediatric HCU are crucial for preventing kidney stone formation and preserving bone health.

Purpose of the Study:

  • To evaluate the long-term efficacy and safety of hydrochlorothiazide (HCT) in pediatric patients with renal hypercalciuria.
  • To assess the impact of HCT on renal calcium excretion, serum biochemistry, and bone mineral content.

Main Methods:

  • A cohort of 30 children (aged 4-13 years) with HCU received 1 mg/kg/day of HCT for an average of 2.5 years.
  • Comprehensive monitoring included urinary calcium, serum electrolytes, parathyroid hormone, nephrogenic cAMP, and bone mineral content.

Main Results:

  • HCT demonstrated rapid and sustained correction of HCU.
  • Significant increases in bone mineral content and reductions in serum cPTH and ncAMP were observed.
  • The treatment effectively prevented new stone formation or growth of existing stones, with no reported side effects.

Conclusions:

  • Hydrochlorothiazide is a safe and effective long-term treatment for renal hypercalciuria in children.
  • HCT improves bone mineral density and reduces the risk of kidney stone recurrence in this pediatric population.

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