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Invasive Salmonella virchow infection in childhood
M Bitsori1, E Galanakis, S Maraki
1Department of Paediatrics, University of Crete, Heraklion, Greece.
Abstract:
Salmonella virchow is generally considered to be one of the less invasive non-typhoidal Salmonellae species; however, several invasive cases have previously been reported. We report 3 cases of otherwise healthy children with S. virchow bacteraemia, monoarthritis and prevertebral abscess, only 1 of whom had previously had gastroenteritis. All 3 children responded to antibiotic regimens consisting of cefotaxime for 10 d, ceftriaxone for 3 weeks and ceftriaxone plus clindamycin for 4 weeks, respectively. In conclusion, S. virchow may be a more invasive serotype in immunocompetent children and present with a wider spectrum of manifestations than considered previously.
Insights
Salmonella virchow can cause invasive infections like bacteremia and abscesses in healthy children, challenging previous assumptions about its lower invasiveness. Prompt antibiotic treatment is crucial for recovery.
Area of Science:
- Pediatric Infectious Diseases
- Microbiology
- Clinical Medicine
Background:
- Salmonella virchow is typically classified as a less invasive non-typhoidal Salmonella serotype.
- Previous reports have indicated sporadic invasive cases, but its potential for broader invasive disease in children was not well-established.
Observation:
- Three otherwise healthy children presented with Salmonella virchow bacteremia.
- These cases were complicated by monoarthritis and prevertebral abscess, with only one child having a history of gastroenteritis.
Findings:
- The study details successful treatment of these invasive Salmonella virchow infections using various antibiotic regimens, including cefotaxime, ceftriaxone, and clindamycin.
- All three children responded well to their respective antibiotic courses, indicating effective therapeutic options.
Implications:
- Salmonella virchow may exhibit greater invasive potential in immunocompetent children than previously recognized.
- This serotype can manifest with a wider range of clinical presentations, including severe systemic infections, necessitating increased clinical vigilance.