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Organic acids in post-mortem cerebrospinal fluid.

M Coude1, P Kamoun

  • 1Laboratoire de Biochimie médicale B, Hôpital Necker Enfants malades, France.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|March 31, 1992
PubMed
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Post-mortem cerebrospinal fluid (CSF) analysis revealed unique organic acids in infant samples compared to controls. Concentrations of malic acid, lactyllactic acid, and uracil correlated with delayed sample collection in deceased infants.

Area of Science:

  • Biochemistry
  • Neuroscience
  • Forensic Science

Background:

  • Cerebrospinal fluid (CSF) organic acid profiles are crucial biomarkers for neurological health.
  • Understanding post-mortem changes in CSF is vital for interpreting findings in forensic and clinical investigations.

Purpose of the Study:

  • To investigate the differences in organic acid profiles between post-mortem and control CSF samples from infants.
  • To identify specific organic acids that may be indicative of post-mortem degradation or specific conditions.

Main Methods:

  • Gas chromatography-mass spectrometry (GC-MS) was employed to analyze organic acids in CSF.
  • CSF samples were obtained from 29 post-mortem infants and 10 living, hospitalized children (controls).

Main Results:

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  • The overall organic acid profiles were similar between post-mortem and control infant CSF.
  • Eight organic acids were detected in post-mortem CSF but not in control samples.
  • Elevated concentrations of malic acid, lactyllactic acid, and uracil in post-mortem CSF correlated with the time delay between death and sample collection.

Conclusions:

  • The presence of specific organic acids in post-mortem CSF can be influenced by post-mortem interval.
  • Malic acid, lactyllactic acid, and uracil may serve as indicators of sample degradation or post-mortem changes in infant CSF.
  • GC-MS analysis of CSF is a valuable tool for differentiating between ante-mortem and post-mortem biochemical states.