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Related Experiment Videos

Thiazide-induced pulmonary edema: a case report.

M J Garcia1, Z Kidwai, J Rosa

  • 1Department of Medicine, St. Vincent's Medical Center.

Connecticut Medicine
|April 1, 1992
PubMed
Summary

Hydrochlorothiazide can cause a rare, severe, and life-threatening idiosyncratic reaction leading to acute pulmonary edema. This non-cardiac pulmonary edema typically resolves with supportive care.

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Area of Science:

  • Pharmacology
  • Pulmonology
  • Internal Medicine

Background:

  • Hydrochlorothiazide is a common diuretic used to treat hypertension.
  • Idiosyncratic drug reactions can manifest with diverse and severe clinical presentations.
  • Pulmonary edema is typically associated with cardiac dysfunction.

Observation:

  • A 42-year-old female presented with acute, severe respiratory distress 30 minutes post-hydrochlorothiazide ingestion.
  • Clinical examination and chest radiography revealed pulmonary edema.
  • Cardiac function was ruled out by normal electrocardiogram, echocardiogram, and radionuclide ventriculogram.

Findings:

  • The patient's condition was diagnosed as non-cardiac pulmonary edema secondary to an idiosyncratic reaction to hydrochlorothiazide.
  • The patient responded well to supportive treatment.
  • Radiographic abnormalities resolved over several days.

Implications:

  • This case highlights an unusual but critical adverse effect of hydrochlorothiazide.
  • Clinicians should consider hydrochlorothiazide-induced pulmonary edema in patients presenting with acute respiratory distress.
  • Early recognition and supportive management are crucial for favorable outcomes in this rare reaction.

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