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Related Experiment Videos

Pathological aspects of Australian Stringhalt.

R F Slocombe1, P J Huntington, S C Friend

  • 1Veterinary Clinical Centre, University of Melbourne, Victoria, Australia.

Equine Veterinary Journal
|May 1, 1992
PubMed
Summary

Australian Stringhalt in horses causes peripheral nerve and muscle damage, specifically affecting large myelinated nerve fibers. This leads to neurogenic muscle atrophy, but the exact cause of this condition remains unknown.

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Area of Science:

  • Veterinary Pathology
  • Neuropathology
  • Equine Medicine

Background:

  • Australian Stringhalt is a debilitating neurological condition in horses.
  • Previous studies have indicated neuromuscular involvement, but detailed pathological findings are limited.

Purpose of the Study:

  • To conduct a detailed pathological examination of tissues from horses with Australian Stringhalt.
  • To characterize the specific lesions in peripheral nerves and muscles.
  • To investigate the potential mechanisms underlying the observed pathology.

Main Methods:

  • Post-mortem examination of nine horses with clinical Australian Stringhalt.
  • Histopathological and morphometric analysis of peripheral nerves (including superficial peroneal, deep peroneal, distal tibial, plantar digital, volar, and recurrent laryngeal nerves).

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  • Histochemical evaluation of specific muscles (long and lateral digital extensors).

    • Main Results:

    • Lesions were confined to peripheral nerves and muscles, with selective loss of large diameter myelinated axons in affected nerves.
    • Observed nerve changes included demyelination, fibrosis, and onion-bulb formation.
    • Significant muscle atrophy and fibrosis were noted, particularly in the long and lateral digital extensors, with a reduction in type II fibers.

    Conclusions:

    • The pathological findings are consistent with a distal axonopathy leading to neurogenic muscle atrophy in Australian Stringhalt.
    • The distribution of lesions suggests susceptibility of longer, larger myelinated nerve fibers to injury.
    • The underlying cause of this distal axonopathy in Australian Stringhalt remains unidentified.