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Related Experiment Videos

Dermatofibrosarcoma protuberans: treatment and prognosis.

E J Rutgers1, B B Kroon, C E Albus-Lutter

  • 1Department of Surgical Oncology, The Netherlands Cancer Institute, Amsterdam.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|June 1, 1992
PubMed
Summary

Wide surgical excision is crucial for treating dermatofibrosarcoma protuberans (DFSP), a rare skin tumor. Achieving wide margins (2-3 cm) significantly reduces local recurrence rates, offering long-term tumor-free survival.

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Area of Science:

  • Oncology
  • Dermatology
  • Surgical Pathology

Background:

  • Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive skin neoplasm.
  • DFSP exhibits a high propensity for local recurrence, posing treatment challenges.

Purpose of the Study:

  • To evaluate the efficacy of wide surgical excision in managing primary and recurrent DFSP.
  • To determine optimal surgical margins for preventing local recurrence.

Main Methods:

  • Retrospective analysis of 19 DFSP cases.
  • Comprehensive literature review of 913 reported DFSP cases.
  • Assessment of recurrence rates based on excision margins and treatment modalities.

Main Results:

  • Wide excision (≥2 cm) resulted in no local recurrences in the study cohort (mean follow-up 13.2 years).

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  • Literature review indicates an overall DFSP recurrence rate of approximately 50%, reduced to 13% with adequate wide excision.
  • Recurrent DFSP treated with wide re-excision had a 12% recurrence rate. Distant metastases are infrequent but carry a poor prognosis.

    • Conclusions:

    • Wide surgical excision with 2-3 cm margins, including fascia, is the recommended treatment for primary and recurrent DFSP.
    • Elective lymph node dissection is not advised for DFSP.
    • The role of radiotherapy remains unclear; surgical management is paramount.