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Published on: February 3, 2015
First clinical experience with a dedicated PET for hanging breast molecular imaging
B B Koolen1, T S Aukema, A J González Martínez
1Department of Nuclear Medicine, the Netherlands Cancer Institute, Amsterdam, the Netherlands. b.koolen@nki.nl
Summary
A new high-resolution breast PET system (MAMMI PET) effectively detects tumors in stage II and III breast cancer patients. While FDG uptake values differ from conventional PET/CT, MAMMI PET shows promise for monitoring neoadjuvant therapy response.
Area of Science:
- Nuclear Medicine
- Oncology
- Medical Imaging
Background:
- A novel high-resolution dedicated positron emission tomography (PET) system for hanging breast imaging, MAMMI PET, has been developed.
- This system aims to enhance primary tumor detection and characterization in breast cancer patients.
Purpose of the Study:
- To evaluate the feasibility of MAMMI PET for tumor detection in patients with stage II and III breast cancer.
- To assess the accuracy of FDG uptake measurements using MAMMI PET compared to conventional PET/CT.
Main Methods:
- Thirty-two patients with invasive breast cancer underwent both conventional PET/CT and MAMMI PET.
- Imaging was performed with 180-240 MBq of FDG, with MAMMI PET scans acquired later post-injection.
- Primary tumor detection and maximum standardized uptake value (SUVmax) were calculated for both modalities.
Main Results:
- MAMMI PET and conventional PET/CT visualized the primary tumor in 97% of patients.
- High agreement was observed in FDG uptake measurements (r=0.86).
- MAMMI PET consistently showed higher SUVmax values compared to PET/CT (average ratio of 2.7).
Conclusions:
- The dedicated high-resolution breast PET system with hanging breast technique effectively visualizes breast tumors, including those near the thoracic wall.
- MAMMI PET may be suitable for sequential assessment of treatment response in patients receiving neoadjuvant systemic therapy.
- Direct comparison of SUVmax values between MAMMI PET and standard PET/CT requires caution due to observed differences.
