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A comparison between the Rappaport Classification and Working Formulation in cooperative group trials: the ECOG
R S Neiman1, K Cain, Y Ben Arieh
1Hematopathology Division, Indiana University Medical Center, Indianapolis 46202.
Hematologic Pathology
|January 1, 1992
Summary
The Working Formulation (WF) for non-Hodgkin's lymphoma classification is reproducible and clinically relevant. Modifications allow its effective use in cooperative oncology groups, enhancing lymphoma diagnosis.
Area of Science:
- Hematopathology
- Oncology
- Clinical Trials
Background:
- The Working Formulation (WF) for non-Hodgkin's lymphoma classification demonstrated reproducibility and clinical relevance.
- The WF's utility within NCI-supported cooperative clinical oncology groups remained untested.
Purpose of the Study:
- To compare the concordance and practical utility of the Working Formulation (WF) against the Rappaport Classification (RC).
- To assess the WF's applicability in cooperative clinical oncology group settings.
Main Methods:
- A retrospective study was conducted by the Hematopathology Subcommittee of the Eastern Cooperative Oncology Group (ECOG).
- Concordance and practical utility between the WF and RC were evaluated using existing data.
Main Results:
- The Working Formulation (WF) showed good concordance and clinical relevance.
- The WF demonstrated practical utility for lymphoma classification within the ECOG framework.
- Modifications were identified to minimize unclassifiable lymphomas, improving WF applicability.
Conclusions:
- The Working Formulation (WF) is a reproducible and clinically relevant classification system for non-Hodgkin's lymphomas.
- With specific modifications, the WF can be effectively implemented in cooperative clinical oncology groups.
- The WF offers a viable alternative for lymphoma classification in large-scale clinical studies.