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Updated: Jul 18, 2026

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Published on: April 28, 2007
Of mice and men: the iron age
Sophie Vaulont1, Dan-Qing Lou, Lydie Viatte
1Institut Cochin, INSERM 567, CNRS 8104, Université Paris 5, Paris, France. vaulont@cochin.inserm.fr
Abstract:
Recently, mutations causing juvenile hemochromatosis have been identified in a novel gene, hemojuvelin (HJV), located on chromosome 1. Mouse models of this disease have now been developed by 2 groups, Huang et al. and Niederkofler et al., through targeted disruption of the Hjv gene (see the related articles beginning on pages 2180 and 2187). These mutant mice will allow further investigation into the role of HJV in the regulation of iron homeostasis, a role that to date remains elusive.
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