Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

3.3K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.3K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.1K
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

7.5K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
7.5K
Disorders of Hemostasis01:24

Disorders of Hemostasis

2.0K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
2.0K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

2.0K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.0K
Sulfur Assimilation01:20

Sulfur Assimilation

314
Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to...
314

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Skin hepcidin overexpression is sufficient to promote systemic iron deficiency.

Haematologica·2026
Same author

Impaired iron balance and erythrocytosis: a complex relationship.

Blood cancer journal·2026
Same author

[Intestinal production of hepcidin reduces iron absorption: a new weapon against iron overload disorders?]

Medecine sciences : M/S·2026
Same author

Intestinal hepcidin overexpression promotes iron deficiency anemia and counteracts iron overload via DMT1 downregulation.

Blood·2025
Same author

Hepcidin and Tissue-Specific Iron Regulatory Networks.

Advances in experimental medicine and biology·2025
Same author

Essential role of hepcidin in host resistance to disseminated candidiasis.

Cell reports·2025

Related Experiment Video

Updated: Jan 12, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

2.3K

Iron-Skin Axis: Exploring the Interplay between Iron Homeostasis and Skin Disorders.

Doha Chrayteh1, Sophie Vaulont1, Carole Peyssonnaux1

  • 1Institut Cochin, CNRS, INSERM, Université Paris Cité, Paris, France; Initiatives IdEx Globule Rouge d'Excellence (InIdex GR-Ex), Université Paris Cité, Paris, France.

The Journal of Investigative Dermatology
|October 31, 2025
PubMed
Summary

Iron is crucial for skin health, impacting everything from healing to pigmentation. Imbalances in iron are linked to skin diseases and offer new therapeutic targets.

Keywords:
Cutaneous infectionCutaneous inflammationFerroptosisIron homeostasisWound healing

More Related Videos

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

5.5K
Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII
04:48

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII

Published on: May 4, 2020

8.6K

Related Experiment Videos

Last Updated: Jan 12, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

2.3K
Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

5.5K
Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII
04:48

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII

Published on: May 4, 2020

8.6K

Area of Science:

  • Dermatology
  • Iron Metabolism
  • Cutaneous Biology

Background:

  • Iron is essential for skin homeostasis, influencing keratinocyte proliferation, pigmentation, immunity, and wound healing.
  • The hepcidin-ferroportin axis is a key regulator of iron levels in the skin.

Purpose of the Study:

  • To review the diverse roles of iron in skin physiology and pathology.
  • To explore the implications of iron dysregulation in dermatological conditions.
  • To discuss therapeutic strategies targeting the iron-skin axis.

Main Methods:

  • Literature review focusing on iron's role in skin homeostasis and disease.
  • Analysis of the hepcidin-ferroportin axis in cutaneous iron regulation.
  • Examination of iron's involvement in inflammatory skin diseases, infections, and ferroptosis.

Main Results:

  • Iron imbalance contributes to inflammatory skin diseases like psoriasis and atopic dermatitis.
  • Iron affects nutritional immunity and susceptibility to skin infections.
  • Iron-dependent cell death (ferroptosis) is implicated in melanocyte damage, photodamage, and skin cancer.
  • Iron influences hair physiology and skin pigmentation.

Conclusions:

  • The skin actively participates in maintaining iron homeostasis.
  • Targeting the iron-skin axis presents promising therapeutic avenues for dermatologic conditions.
  • Understanding iron metabolism is key to developing novel skin therapies.