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Hepcidin and Tissue-Specific Iron Regulatory Networks.

Samira Lakhal-Littleton1, Carole Peyssonnaux2,3

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Summary

Hepcidin, a liver-secreted hormone, also acts locally in various organs. This local hepcidin influences iron pathways in both health and disease, impacting barrier function and tissue repair.

Keywords:
Barrier functionsCell divisionEndocrine controlHepcidinHost defenseLocal iron regulationRepairTissue housekeeping

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Area of Science:

  • Endocrinology
  • Cell Biology
  • Physiology

Background:

  • Hepcidin is the primary iron-regulating hormone, mainly produced by the liver.
  • Emerging evidence suggests local hepcidin production in non-hepatic tissues.
  • Local hepcidin mediates autocrine/paracrine functions in various physiological and pathophysiological states.

Purpose of the Study:

  • To explore the diverse local roles of hepcidin beyond its endocrine function.
  • To highlight hepcidin's involvement in iron-dependent pathways within specific cells and organs.
  • To discuss hepcidin's contribution to tissue homeostasis and disease pathology.

Main Methods:

  • Review of existing literature on hepcidin's local production and function.
  • Analysis of studies investigating hepcidin in various pathophysiological conditions.
  • Synthesis of data on hepcidin's roles in barrier maintenance, host defense, and tissue repair.

Main Results:

  • Hepcidin exhibits significant autocrine/paracrine activity in multiple organs.
  • Local hepcidin is crucial for iron homeostasis in non-hepatic tissues.
  • Hepcidin plays roles in barrier integrity, immune response, and tissue repair processes.

Conclusions:

  • Hepcidin's functions extend beyond endocrine regulation, with critical local roles.
  • Understanding local hepcidin action is vital for comprehending iron metabolism in health and disease.
  • Targeting local hepcidin may offer therapeutic strategies for various conditions.