Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intact hemispheric specialization for spatial and shape working memory in schizophrenia.

Dara S Manoach1, Nathan White, Kristen A Lindgren

  • 1Department of Psychiatry, Massachusetts General Hospital-East, Charlestown, MA 02129, USA. dara@nmr.mgh.harvard.edu

Schizophrenia Research
|August 4, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adopting common data elements for the National Trauma Research Repository through a consensus meeting: the trauma core.

Trauma surgery & acute care open·2026
Same author

Sodium-Glucose Cotransporter 2 Inhibitors and Dementia Risk in Patients With Psychiatric Disorders.

JAMA network open·2026
Same author

Brain regional susceptibility to tauopathy in individuals at risk for chronic traumatic encephalopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Dose-dependent white matter changes associated with repetitive head impacts in former American football players.

Brain communications·2026
Same author

Impaired Hippocampal Circuitry and Memory Dysfunction in Schizophrenia.

Nature. Mental health·2026
Same author

High prevalence of CNS-directed autoantibodies in patients with schizophrenia.

bioRxiv : the preprint server for biology·2026

Patients with schizophrenia exhibit intact hemispheric specialization in the ventrolateral prefrontal cortex (PFC) for spatial and shape working memory (WM), similar to healthy individuals. Their working memory deficits may stem from executive function impairments rather than strategy adoption failures.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Psychiatry

Background:

  • Schizophrenia is associated with working memory (WM) deficits.
  • Previous research suggests impaired brain function in schizophrenia, but specific mechanisms for WM deficits are unclear.
  • Hemispheric specialization in prefrontal cortex (PFC) is crucial for cognitive functions like WM.

Purpose of the Study:

  • To investigate hemispheric specialization in the ventrolateral PFC for spatial and shape working memory (WM) in schizophrenia patients compared to healthy controls.
  • To determine if reduced specialization in schizophrenia contributes to WM deficits.
  • To test the hypothesis that schizophrenia patients fail to adopt optimal domain-specific strategies for WM.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to study brain activity.

Related Experiment Videos

  • Twelve healthy subjects and 16 schizophrenia patients performed spatial WM, shape WM, and a control task.
  • Direct comparisons between spatial and shape WM tasks assessed relative hemispheric specialization.

    • Main Results:

    • Both schizophrenia patients and healthy controls demonstrated intact relative hemispheric specialization in the ventrolateral PFC.
    • Spatial WM showed specialization in the right PFC, while shape WM showed specialization in the left PFC.
    • No significant differences in hemispheric specialization were found between patients and controls, despite patients' poorer WM performance.

    Conclusions:

    • Schizophrenia patients maintain normal hemispheric specialization in the ventrolateral PFC for spatial and shape WM.
    • This suggests patients utilize similar domain-specific strategies as healthy individuals.
    • WM deficits in schizophrenia are likely due to impaired executive functions (associated with dorsolateral PFC) rather than strategy deficits.