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[Acute enterovirus uveitis in infants].
Voprosy Virusologii
|August 5, 2005
Summary
Enterovirus uveitis (EU), a novel infant eye disease, was identified in Russia and linked to echovirus subtypes. These viruses caused outbreaks and severe eye complications in over 750 children.
Area of Science:
- Ophthalmology
- Virology
- Pediatrics
Context:
- Enterovirus uveitis (EU) emerged in infants in Russia in the early 1980s.
- Nosocomial outbreaks affected over 750 children, primarily under one year old.
- Sporadic cases were also identified in Russia and former Soviet Union countries.
Purpose:
- To review the epidemiology, clinical manifestations, and pathogenesis of enterovirus uveitis.
- To highlight the role of specific echovirus subtypes in infant eye disease.
- To discuss experimental findings on uveitis and sepsis-like disease in primates.
Summary:
- Human echoviruses (EV19K, EV11A, EV11/B) caused significant outbreaks of enterovirus uveitis (EU) in Russian infants.
- Clinical signs included acute uveitis with potential severe complications like cataracts and glaucoma.
- Experimental infections in primates confirmed the pathogenicity of uveitis strains, causing ocular disease and sepsis.
Impact:
- Established enteroviruses as a cause of infant uveitis and associated complications.
- Provided insights into the phylogenetic and pathogenetic links between uveitis and sepsis strains.
- Contributed to understanding infant infectious eye diseases and their sequelae.