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Published on: December 27, 2016
Biological evaluation of 2-aryl-2-fluoropropionic acids as possible platforms for new medicinal agents
Yoshio Takeuchi1, Hidehito Fujisawa, Tomoya Fujiwara
1Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-0194, Japan. takeuchi@ms.toyama-mpu.ac.jp
Abstract:
We investigated the cyclooxygenase (COX) inhibitory and anticancer activities of 2-aryl-2-fluoropropionic acids 1a-e. These fluorinated compounds showed lower inhibitory activity toward COX-1 than the corresponding non-fluorinated compounds 2a-e with retained inhibitory activity against COX-2 resulting in modification of the balance of COX-1/COX-2 inhibitions, and they showed little anticancer activity. Interesting differences of the activities between (S)- and (R)-enantiomers were observed in some cases.
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