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Type III mixed cryoglobulinemia associated with digital necrotic ulcer successfully treated with intermittent

Omer Cakir¹, Orhan Ayyildiz, Abdurrahman Isikdogan

¹Department of Cardiovascular, Dicle University of Medicine, Diyarbakir, Turkey. omercak@dicle.edu.tr

|August 5, 2005

Abstract:

Cryoglobulinemic vasculitis is an immune complex-mediated vasculitis predominantly affecting small vessels. The authors report an 18-year-old woman with painful digital necrotic ulcer due to type III cryoglobulinemic vasculitis on the basis of systemic lupus erythematosus. Serum protein electrophoresis and immunoelectrophoresis demonstrated a polyclonal peak of the immunoglobulin Glambda (IgGlambda) and IgMlambda type. The patient was successfully treated with intermittent intravenous pulse cyclophosphamide.

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