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Updated: Aug 16, 2026
Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
[Vascularized pedicle iliac crest for the repair of bone and soft tissue defect of lower extremity]
Ke-jian Wu1, Shu-xun Hou, Wei-jia Zhang
1Department of Orthopedics, The 304th Hospital of People's Liberation Army, Beijing 100037, China. wkjian@163.com
Objective:
To study the role of transplantation of the vascularized pedicle iliac crest for the repair of bone and soft tissue defect of lower extremity.
Methods:
The vascularized pedicle iliac crest was designed for the repair of bone and soft tissue defect of lower extremity according to anatomic feature of leg and foot. Skin graft was used for coverage of the iliac flap.
Results:
Skin survival could demonstrate the survival of the vascularized pedicle iliac crest indirectly one week postoperatively. Skin survived completely in 4 cases and partly in 3 cases. Callus was seen at the transplantation site one month postoperatively, and K-wires were removed 4 months later in the cases of metatarsal defect. The external fixators were removed in the cases of tibia defect 6 to 8 months postoperatively. The functions of lower extremities were restored in 2 to 4 months. The bone and soft tissue defects were repaired, and ultimate function and cosmetic effects were satisfied after the mean follow up of 10 months (ranged from 6 to 15 months).
Conclusion:
Transplantation of the vascularized pedicle iliac crest is an ideal method for the repair of bone and soft tissue defect of lower extremity. The operation can be performed in one stage. The functions and cosmetic effects are better than the traditional methods.
