Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Murine models of COPD.

G G Brusselle1, K R Bracke, T Maes

  • 1Department of Respiratory Diseases, Ghent University Hospital and Ghent University, Belgium.

Pulmonary Pharmacology & Therapeutics
|August 9, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Silent Spill - maritime microplastics from vessel coatings.

The Science of the total environment·2026
Same author

A scenario-based risk assessment framework for tyre wear particles in European seas.

Journal of hazardous materials·2026
Same author

A large-scale study of microplastic abundance in sediment cores from the UK continental shelf and slope.

Marine pollution bulletin·2022
Same author

The ALPACA study: (In)Appropriate LAMA prescribing in asthma: A cohort analysis.

Pulmonary pharmacology & therapeutics·2021
Same author

Taking a mass-balance approach to assess marine plastics in the South China Sea.

Marine pollution bulletin·2021
Same author

Effect of Theophylline on Endotoxin and Tumor Necrosis Factor Induced Airway Changes in an in vivo Animal Model.

International archives of allergy and immunology·2021
Same journal

Brain-derived neurotrophic factor (BDNF) signaling in respiratory disease: Mechanisms, neuroimmune crosstalk, and therapeutic implications.

Pulmonary pharmacology & therapeutics·2026
Same journal

PD05, a novel neutrophil elastase inhibitor, mitigates LPS-induced acute lung injury in a preclinical model.

Pulmonary pharmacology & therapeutics·2026
Same journal

The preclinical discovery and development of depemokimab for severe eosinophilic asthma.

Pulmonary pharmacology & therapeutics·2026
Same journal

TROP2 as a promising therapeutic target in lung cancer: Current clinical trial landscape and future directions.

Pulmonary pharmacology & therapeutics·2026
Same journal

Synergistic induction of apoptosis in lung cancer cells via TOP2A targeting through combined dihydroartemisinin and chrysin treatment.

Pulmonary pharmacology & therapeutics·2026
Same journal

Evodiamine protects against lung ischemia-reperfusion injury by attenuating SYK-associated TLR4/NLRP3 inflammasome activation and ferroptosis-related injury signatures.

Pulmonary pharmacology & therapeutics·2026
See all related articles

Murine models are crucial for understanding chronic obstructive pulmonary disease (COPD) pathogenesis. Researchers use enzyme instillation, noxious stimuli inhalation, and transgenic mice to study COPD mechanisms.

Area of Science:

  • Pulmonary Medicine
  • Immunology
  • Genetics

Background:

  • Chronic obstructive pulmonary disease (COPD) involves irreversible airflow limitation and lung inflammation.
  • Pathogenesis is linked to airway resistance and lung tissue destruction.
  • In vivo animal models, especially mice, are vital for studying COPD's molecular and cellular mechanisms.

Purpose of the Study:

  • To explore the utility of murine models in unraveling COPD pathogenesis.
  • To detail experimental approaches for mimicking COPD traits in mice.

Main Methods:

  • Enzyme instillation to induce emphysema-like lesions, supporting the protease-antiprotease imbalance hypothesis.
  • Inhalation of noxious stimuli like tobacco smoke, SO2, NO2, or ozone to create COPD-like lesions.

Related Experiment Videos

  • Utilizing transgenic mice with gene overexpression or depletion, alone or combined with other methods.

    • Main Results:

    • These models effectively mimic key aspects of COPD, including emphysema and inflammation.
    • Gene manipulation in transgenic mice provides insights into specific gene functions and disease mechanisms.
    • Combined approaches offer comprehensive data on COPD pathophysiology.

    Conclusions:

    • Murine models are indispensable tools for investigating the complex mechanisms of COPD.
    • Experimental strategies like enzyme instillation, noxious gas exposure, and genetic modification in mice advance COPD research.