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Updated: Jul 28, 2026
A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats
Published on: March 23, 2018
Xenon and the inflammatory response to cardiopulmonary bypass in the rat
Jeffrey A Clark1, Daqing Ma, H Mayumi Homi
1Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
Objective:
The purpose of this study was to investigate the effect of xenon on the inflammatory response to cardiopulmonary bypass.
Design:
Prospective, randomized experimental study.
Setting:
University research laboratory.
Participants:
Sprague-Dawley rats.
Interventions:
After surgical preparation, rats were randomly divided into 4 groups: (1) SHAM rats were cannulated but did not undergo cardiopulmonary bypass; (2) cardiopulmonary bypass rats were subjected to 60 minutes of cardiopulmonary bypass using an oxygenator receiving a 30% O(2), 65% N(2), and 5% CO(2) gas mixture; (3) MK801 rats received MK801 (0.15 mg/kg intravenous) 15 minutes before 60 minutes of cardiopulmonary bypass with the same gas mixture; and (4) xenon rats underwent 60 minutes of cardiopulmonary bypass receiving a 30% O(2), 60% xenon, 5% N(2), and 5% CO(2) gas mixture.
Measurements And Main Results:
All bypass groups showed elevations in both cytokines compared with the SHAM-operated group. However, the inflammatory response to cardiopulmonary bypass in the group receiving xenon was no different from the other bypass groups.
Conclusions:
Xenon appears to have no effect on the inflammatory response to cardiopulmonary bypass, making its previously described neuroprotective effect during cardiopulmonary bypass likely independent of any inflammation modulation.
