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07:35
Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
Emerging therapies for polycystic kidney disease
1Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. vgattone@iupui.edu
Current Opinion in Pharmacology
|August 9, 2005
Summary
Polycystic kidney diseases are inherited conditions lacking treatments. Research in animal models shows potential therapies, including vasopressin V(2) receptor antagonists, may slow cyst growth.
Area of Science:
- Nephrology
- Genetics
- Pharmacology
Background:
- Polycystic kidney diseases (PKDs) are the most prevalent monogenetic inherited disorders.
- Multiple human genes are linked to the development of renal cysts.
- Currently, no approved therapies exist to halt the progression of cystic kidney pathology.
Purpose of the Study:
- To review current and potential therapeutic strategies for polycystic kidney diseases.
- To highlight emerging treatments based on preclinical animal studies.
Main Methods:
- Review of animal studies investigating therapeutic interventions for PKD.
- Focus on mechanisms targeting cystogenesis, such as cAMP regulation and growth factor inhibition.
Main Results:
- Vasopressin V(2) receptor antagonists show promise by reducing renal cyclic adenosine monophosphate (cAMP), a key factor in cyst enlargement.
- Other potential therapies under investigation include c-myc antisense oligonucleotides and epidermal growth factor receptor tyrosine kinase inhibitors.
Conclusions:
- Multiple therapeutic approaches will likely be required to effectively treat the diverse genetic causes and multiorgan involvement seen in PKDs.
- Targeting specific molecular pathways offers potential for slowing disease progression.
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