Immunohistochemical characterization of experimental Greene melanoma

20 experimental amelanotic Greene melanomas implanted into the anterior chamber of rabbit eyes were examined immunohistochemically in paraffin sections. All the Greene melanomas were found to be positive for vimentin, S-100 and HMB 45 and negative for alpha-human chorionic gonadotropin, neuron-specific enolase, chromogranin, synaptophysin, cytokeratin, carcino-embryonic antigen, serotonin, desmin and pan leukocyte marker T-200. Greene melanoma is comparable with human cutaneous and uveal melanoma in its immunohistochemical reaction pattern.