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Blood glucose: a strong risk factor for mortality in nondiabetic patients with cardiovascular disease

Sidney C Port1, Mark O Goodarzi, Noel G Boyle

  • 1Department of Statistics, University of California, Los Angeles, CA 90095-1555, USA. sport@ucla.edu

American Heart Journal
|August 10, 2005
PubMed

Insights

Blood glucose levels, even within the normal range, significantly predict mortality in cardiovascular disease patients. Higher blood glucose correlates with increased risk of death, even without diabetes.

Area of Science:

  • Cardiovascular Medicine
  • Metabolic Health
  • Clinical Research

Background:

  • Prognostic significance of blood glucose (BG) in nondiabetic patients with stable cardiovascular disease (CVD) is understudied.
  • Little is known about mortality risk related to normal blood glucose ranges in these patients.

Purpose of the Study:

  • To investigate the relationship between random blood glucose levels and mortality in nondiabetic patients with existing CVD.
  • To determine if there is a graded mortality risk across normal blood glucose ranges and if a lower threshold exists.

Main Methods:

  • Utilized 30-year Framingham Heart Study data.
  • Analyzed 2-year all-cause, cardiovascular mortality (CVM), and non-CVM risk.
  • Adjusted for age, sex, and traditional CVD risk factors in nondiabetic subjects without glucose intolerance.

Main Results:

  • Demonstrated a steep, graded relationship between blood glucose and mortality across normal and subdiabetic ranges.
  • Mortality risk increased continuously from the lowest normal BG (60 mg/dL) to the highest considered (119 mg/dL).
  • No lower threshold for increased mortality risk was observed within the normal blood glucose range.

Conclusions:

  • Blood glucose within the normal range is a significant independent predictor of mortality in nondiabetic CVD patients.
  • Elevated blood glucose, even if not diabetic, carries prognostic weight for high-risk cardiovascular patients.
  • Findings highlight the importance of monitoring blood glucose in CVD management.
Abstract

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