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Total synthesis of scutellarin-7-O-glucuronide
Jian-Mei Cui1, Gang Fang, Ya-Bo Duan
1Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China.
Journal of Asian Natural Products Research
|August 10, 2005
Abstract:
Scutellarin-7-O-glucuronide (1) has been synthesized from 2-hydroxyl-4,5,6-trimethoxyacetophenone through eight steps, including Michael addition, cyclization, hydrogenation, hydroxyl protection, deprotection, etc. The overall yield of 13% is much higher than that reported (0.6%) by L. Farkas, G. Mezey-Vàndor et al. in 1974.

