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Updated: Aug 16, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
Lipid transport into bile and role in bile formation
Albert K Groen1, Ronald P J Oude Elferink
1Amsterdam Liver Center, Academic Medical Center, Amsterdam, The Netherlands. A.K.groen@amc.uva.nl
Abstract:
Biliary lipid secretion is driven by bile salts, the primary metabolites of cholesterol. Transport of bile salts as well as phospholipids and cholesterol is mediated by ATP Binding Cassette (ABC) transporters. Expression of these transporters is regulated in a coordinate fashion by a set of nuclear hormone receptors explaining the old observation of coupling between bile salt secretion and biliary lipid secretion. Although it is now clear which proteins are involved, the molecular mechanism of biliary lipid secretion is still unresolved. In addition, scarce information is available about the systems responsible for intracellular transport of cholesterol, phospholipid and bile salt. These issues form the subject of the review.
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