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Eight base changes are sufficient to convert a leucine-inserting tRNA into a serine-inserting tRNA

J Normanly1, T Ollick, J Abelson

  • 1Division of Biology, California Institute of Technology, Pasadena 91125.

Proceedings of the National Academy of Sciences of the United States of America
|June 15, 1992
PubMed
Summary

Aminoacyl-tRNA synthetases distinguish tRNAs through specific recognition. Researchers identified eight key changes in transfer RNA structures, specifically in the acceptor and D stems, to convert a leucine tRNA to serine identity.

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