Related Experiment Video
Updated: Aug 12, 2026

A Simple, Robust, and High Throughput Single Molecule Flow Stretching Assay Implementation for Studying Transport of Molecules Along DNA
Published on: October 1, 2017
Langevin trajectories between fixed concentrations
1Department of Mathematics, Yale University, 10 Hillhouse Avenue P.O. Box 208283, New Haven, Connecticut 06520-8283, USA.
Abstract:
We consider the trajectories of particles diffusing between two infinite baths of fixed concentrations connected by a channel, e.g., a protein channel of a biological membrane. The steady state influx and efflux of Langevin trajectories at the boundaries of a finite volume containing the channel and parts of the two baths is replicated by termination of outgoing trajectories and injection according to a residual phase space density. We present a simulation scheme that maintains averaged fixed concentrations without creating spurious boundary layers, consistent with the assumed physics.
Related Concept Videos
Diffusion
Le Chatelier's Principle: Changing Concentration
Protein Diffusion in the Membrane
Mean free path and Mean free time
Analyte Adsorption and Distribution
Fast Reactions

