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A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

Hepatitis C virus infection in HIV-infected patients

Mark S Sulkowski1

  • 1Division of Infectious Diseases, Johns Hopkins Medical Institutions, 1830 East Monument Street, Room 319, Baltimore, MD 21287, USA. msulkows@jhmi.edu

Current HIV/AIDS Reports
|August 11, 2005
PubMed

Insights

Hepatitis C (HCV) and HIV coinfection is common, with HCV-related liver disease causing significant illness in HIV patients. Treatment with pegylated interferon-alpha plus ribavirin is safe and effective for these individuals.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Virology

Background:

  • Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) coinfection affects 15-30% of HIV-infected individuals in the US due to shared transmission routes.
  • HCV-related liver disease is a leading cause of morbidity and mortality in HIV-coinfected patients, particularly with effective antiretroviral therapy (ART).

Purpose of the Study:

  • To review the epidemiology, natural history, and management of HCV in patients coinfected with HIV.
  • To highlight the complexities and recent advancements in treating HCV in this population.

Main Methods:

  • Review of recent randomized controlled trials and guidelines from the Infectious Diseases Society of America and the American Association for the Study of Liver Disease.
  • Focus on evidence regarding the safety, tolerability, and efficacy of HCV treatment in HIV-infected individuals.

Main Results:

  • Pegylated interferon-alpha plus ribavirin has demonstrated safety, tolerability, and efficacy in treating HCV in HIV-infected individuals.
  • Despite comorbidities and ART challenges, HCV treatment is recommended and feasible.

Conclusions:

  • HCV management in HIV-coinfected patients requires careful consideration of comorbidities and ART.
  • Effective HCV treatment options are now available, improving outcomes for coinfected individuals.

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