Related Experiment Video
Updated: Aug 16, 2026
07:33
A Mouse Model of Intestinal Partial Obstruction
Published on: March 5, 2018
[Pathogenetic mechanisms of peritonitis in acute small intestinal obstruction]
Khirurgiia
|August 11, 2005
Abstract:
Microscopic changes in the walls of strangulated small intestine, morphology of their vascular and resorption elements, adaptive mechanisms were studied in experimental acute small intestinal obstruction. It is demonstrated that the main factor of pathogenesis of peritonitis in strangulate and obstructive small intestinal obstruction is morphofunctional changes of intraorganic microcirculation of the small intestine.
Insights
This study investigated changes in strangulated small intestines. Morphofunctional alterations in intraorganic microcirculation are key to peritonitis development in intestinal obstruction.
Area of Science:
- Gastroenterology
- Pathology
- Surgical Research
Background:
- Small intestinal obstruction is a common surgical emergency.
- Strangulation leads to significant tissue damage and potential peritonitis.
- Understanding the underlying pathobiology is crucial for effective treatment.
Purpose of the Study:
- To examine microscopic changes in strangulated small intestine walls.
- To investigate the morphology of vascular and resorption elements.
- To identify adaptive mechanisms in experimental acute small intestinal obstruction.
Main Methods:
- Experimental model of acute small intestinal obstruction.
- Microscopic examination of intestinal wall tissues.
- Morphological analysis of vascular and resorption components.
Main Results:
- Detailed microscopic changes in the small intestine wall were observed.
- Alterations in the morphology of vascular and resorption elements were documented.
- Evidence of adaptive mechanisms in response to obstruction was identified.
Conclusions:
- Morphofunctional changes in intraorganic microcirculation are central to peritonitis pathogenesis.
- These microcirculatory changes are the primary drivers of peritonitis in strangulated and obstructive small intestinal obstruction.
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