Related Experiment Video

Updated: Aug 16, 2026

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
09:15

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

Renal dysfunction after heart transplantation: incidence, prognosis and risk factors

Ron-Bin Hsu1, Robert J Chen, Cheng-Hsin Lin

  • 1Department of Surgery, National Taiwan University Hospital, National Taiwan University College of Medicine and Far Eastern Memorial Hospital, Taipei.

Journal of the Formosan Medical Association = Taiwan Yi Zhi
|August 11, 2005
PubMed

Insights

Heart transplant recipients face a high risk of developing renal dysfunction, impacting long-term survival. Early creatinine levels post-transplant are a key predictor, alongside patient age and pre-transplant kidney function.

Area of Science:

  • Nephrology
  • Cardiology
  • Transplantation Medicine

Background:

  • Chronic renal insufficiency is a significant concern in heart transplant recipients.
  • Risk factors for post-transplant renal dysfunction remain incompletely understood despite extensive experience.

Purpose of the Study:

  • To assess the incidence and prognosis of renal dysfunction after heart transplantation.
  • To identify independent risk factors for developing renal dysfunction post-heart transplant.

Main Methods:

  • Retrospective analysis of 132 adult heart transplant recipients surviving over 1 year.
  • Renal dysfunction defined as serum creatinine ≥ 2.0 mg/dL.
  • Kaplan-Meier method for incidence/prognosis; logistic regression for risk factors.

Main Results:

  • Pre-transplant renal dysfunction was present in 7% of patients.
  • Cumulative incidence of renal dysfunction reached 57.3% by 10 years post-transplant.
  • Independent risk factors included age, pretransplant blood urea nitrogen, and serum creatinine at 6 months.

Conclusions:

  • High incidence of renal dysfunction observed post-heart transplantation.
  • Renal dysfunction is associated with poorer long-term survival.
  • Serum creatinine at 6 months is the strongest predictor, followed by age and pretransplant BUN.
Abstract

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...