Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A new threshold dose-response model including random effects for data from developmental toxicity studies.

Daniel L Hunt1, Shesh N Rai

  • 1Department of Biostatistics, St Jude Children's Research Hospital, 332 N. Lauderdale Street, Memphis, TN 38105-2794, USA.

Journal of Applied Toxicology : JAT
|August 11, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Phase 2 Feasibility Study Combining Pembrolizumab and Metformin in patients with Metastatic Head and Neck Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Urolithin A activates aryl hydrocarbon receptor-NLRP6-mediated pathways in intestinal epithelial cells to modulate mucosal immunity and strengthen gut barrier integrity.

Nature communications·2026
Same author

Impact of high-fat Western diet on chronic lymphocytic leukemia disease progression and gut microbiome profile in Eμ-TCL1 mice.

bioRxiv : the preprint server for biology·2026
Same author

Amivantamab for Recurrent or Metastatic Adenoid Cystic Carcinoma: A Phase 2 Nonrandomized Clinical Trial.

JAMA otolaryngology-- head & neck surgery·2026
Same author

Characterization of the clonal hierarchy and immunophenotype of PTPN11 mutations in acute myeloid leukemia.

JCI insight·2026
Same author

Model-free prognostication of non-linear time series.

PloS one·2026
Same journal

Comprehensive Human Health Risk Assessment of Metal(loid)s in Selected Fish Species and Clams From Nun River, Bayelsa State, Nigeria.

Journal of applied toxicology : JAT·2026
Same journal

Long-Term Hepatorenal Toxicity Assessment of the Vasopressin Receptor Antagonist Conivaptan in Lewis Rats: Implications for Therapeutic Safety.

Journal of applied toxicology : JAT·2026
Same journal

BPA and Male Reproductive Health: Mechanistic Insights, Toxicological Implications, and the Protective Role of Antioxidants.

Journal of applied toxicology : JAT·2026
Same journal

Dosimetry of Inhaled Aerosols: From Exposure to Target Tissue Dose in Risk Assessment and Drug Delivery.

Journal of applied toxicology : JAT·2026
Same journal

Emerging Links Between PFAS Exposure and Autoimmune Thyroid Disease: A Narrative Review of Epidemiologic Evidence, Mechanistic Insights, and Research Gaps.

Journal of applied toxicology : JAT·2026
Same journal

RETRACTION: Predictive Performance of the Vitrigel-Eye Irritancy Test Method Using 118 Chemicals.

Journal of applied toxicology : JAT·2026
See all related articles

This study introduces a random effect (RE) threshold model to better analyze developmental toxicity data. The model accounts for extra variability between animal litters, improving dose-response assessments in teratology studies.

Area of Science:

  • Toxicology
  • Biostatistics
  • Developmental Biology

Background:

  • Standard beta-binomial models struggle with extra variability in teratological dose finding studies.
  • Existing models do not fully capture between-litter variability and correlations within litters.

Purpose of the Study:

  • To investigate a random effect (RE) threshold dose-response model for developmental toxicity studies.
  • To model variability between animal litters in response to toxic agents.

Main Methods:

  • Developed and applied a random effect threshold dose-response model, an extension of the logit model.
  • Utilized an approximate likelihood function for parameter estimation.
  • Conducted a simulation study to evaluate model performance.

Related Experiment Videos

Main Results:

  • The RE threshold model effectively accounts for additional variability beyond the beta-binomial model.
  • Parameter estimates were derived, and the significance of the RE parameter was tested.
  • The simulation study demonstrated the model's capability in parameter estimation.

Conclusions:

  • The random effect threshold model offers an improved approach for analyzing developmental toxicity data.
  • This model better captures inter-litter variability, leading to more accurate dose-response assessments.
  • The findings support the use of the RE threshold model in teratology studies.