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Effective bisquaternary reactivators of tabun-inhibited AChE
Kamil Kuca1, Jiri Cabal, Kamil Musilek
1Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic. kucakam@seznam.cz
Abstract:
Two cholinesterase reactivators (K074 and K075) were synthesized and their reactivation efficacy against tabun-inhibited acetylcholinesterase of the rat brain was tested in vitro. Comparing this efficacy showed that commonly used oximes (pralidoxim, obidoxime and HI-6) were practically without reactivation potency. On the other hand, oximes K074, K075 and trimedoxime were satisfactorily effective. Moreover, K-oximes reactivated tabun-inhibited AChE at lower concentration (10(-4) and 10(-3) m) in comparison with trimedoxime (10(-3) and 10(-2) m). Thus, K-oximes can be considered as the most effective reactivators of tabun-inhibited AChE at present.
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