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Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology
Published on: September 13, 2022
Electrotonic cell-cell interactions in cardiac tissue: effects on action potential propagation and repolarization
1Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis, St. Louis, Missouri 63130-4899, USA. rudy@wustl.edu
Abstract:
This article characterizes through computer simulations, the role of cell-cell interactions and of tissue structure in determining properties of action potential propagation and repolarization in cardiac tissue. The results demonstrate strong interactions between membrane excitatory processes and electrical loading by the passive tissue structure. These interactions modulate the ionic mechanism of conduction and influence conduction velocity and robustness. Cell-cell interactions also have a strong effect on the dispersion of repolarization in cardiac tissue.
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