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Related Experiment Videos

Fully automated solid weighing workstation.

Stephen K-F Wong1, YiFeng Lu, William Heineman

  • 1Department of Neuroscience and Supply Chain Logistics, Pfizer Global Research and Development, Pfizer, Inc., Groton, CT 06340, USA. stephen_wong@groton.pfizer.com

Journal of Biomolecular Screening
|August 12, 2005
PubMed
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This study introduces an automated workstation for weighing solids using an electrostatically charged pipette tip. This innovation significantly reduces hands-on time and sample waste in scientific research.

Area of Science:

  • Analytical Chemistry
  • Laboratory Automation
  • Materials Science

Background:

  • Accurate weighing of small solid samples is crucial for various scientific applications.
  • Manual weighing can be time-consuming, prone to errors, and expose researchers to hazardous materials.
  • Existing automated systems may have limitations in handling diverse solid forms and small quantities.

Purpose of the Study:

  • To develop and validate a fully automated, solid-to-solid weighing workstation.
  • To assess the workstation's performance in handling various solid types and quantities.
  • To evaluate the impact of automation on efficiency, accuracy, and researcher safety.

Main Methods:

  • Utilized an electrostatically charged pipette tip to attract and transfer solid particles.

Related Experiment Videos

  • Employed a microbalance and a spinning mechanism for precise sample deposition into destination vials.
  • Tested the workstation with diverse solid textures (powder, crystalline, liquid, semi-solid) and submilligram sample quantities.
  • Validated accuracy using bovine serum albumin and tested with 48 different synthetic compounds.

    • Main Results:

    • Successfully weighed submilligram quantities (down to 0.3 mg) from source vials containing as little as 1 mg.
    • Achieved a coefficient of variation of less than 6% for protein concentration in 48 samples.
    • Automated weighing time was comparable to manual methods.
    • Reduced hands-on time by 90%, minimizing exposure to toxic compounds and sample waste.

    Conclusions:

    • The automated workstation offers a reliable and efficient method for solid-to-solid weighing.
    • It handles various solid forms and small quantities effectively, enabling testing of milligram-scale synthesized compounds.
    • The system enhances safety, reduces waste, and improves the overall workflow in research laboratories.