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Lung transplantation and interstitial lung disease
Raed Alalawi1, Timothy Whelan, Ravinder S Bajwa
1Division of Pulmonary and Critical Care Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Current Opinion in Pulmonary Medicine
|August 12, 2005
Summary
Lung transplantation offers a viable treatment for respiratory failure in interstitial lung disease (ILD). Survival rates after ILD lung transplant are comparable to those for other lung transplant recipients.
Area of Science:
- Pulmonology
- Transplant Surgery
Background:
- Interstitial lung disease (ILD) encompasses diverse conditions causing respiratory failure and mortality.
- Lung transplantation is a critical therapeutic option for eligible ILD patients.
Purpose of the Study:
- To review current indications, procedures, and outcomes for lung transplantation in ILD.
- To highlight factors influencing transplant choices and post-transplant management in ILD.
Main Methods:
- Review of current literature on lung transplantation for interstitial lung disease.
- Analysis of factors affecting procedure selection (single vs. bilateral lung transplant).
- Evaluation of outcomes, morbidity, mortality, and recurrence specific to ILD patients.
Main Results:
- Lung transplant indications and outcomes for ILD are continually advancing.
- Recipient comorbidities significantly impact the choice between single and bilateral lung transplants.
- Bilateral transplants are typically reserved for specific conditions like suppurative lung disease or pulmonary hypertension.
Conclusions:
- Lung transplantation demonstrates effectiveness in treating respiratory failure due to ILD.
- Post-transplant survival for ILD patients is comparable to recipients with other underlying diseases.