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Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
Renal hypertrophic infundibular stenosis
Randall Craver1, Rebecca Boyd, Kenneth Ward
1Department of Pathology, Louisiana State University Health Sciences Center, Children's Hospital of New Orleans, 200 Henry Clay Ave., New Orleans, LA 70118, USA. rcrave@lsuhsc.edu
Abstract:
Bilateral hydrocalycosis secondary to radiographically demonstrated bilateral infundibular stenosis required a left nephrectomy in an 18-year-old young man. The infundibular narrowing was due to marked hyperplasia of the submucosal smooth muscle. Scattered within the hypertrophic smooth muscle were rare spindled CD117-positive interstitial cells, similar to the cells responsible for peristaltic pacemaker activity within the gastrointestinal tract. The admixture of CD117 cells suggests this is a true muscular hyperplasia rather than a leiomyomatosis. The stimulus to the hyperplasia is unknown.
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