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Intercellular adhesion molecule (ICAM-1) response after major neonatal surgery
Hiroyuki Koga1, Hiroyuki Kobayashi, Atsuyuki Yamataka
1Department of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Pediatric Surgery International
|August 13, 2005
Summary
Surgical stress elevates intercellular adhesion molecule (ICAM)-1 in neonates. While ICAM-1 levels rise after major surgery, intestinal procedures show a longer-lasting response, indicating potential endothelial damage markers.
Area of Science:
- Neonatal surgery
- Endothelial cell biology
- Inflammatory markers
Background:
- Surgical stress triggers systemic responses impacting endothelial cells (EC).
- Intercellular adhesion molecule (ICAM)-1 is a key marker of EC activation and inflammation.
Purpose of the Study:
- To investigate the ICAM-1 response to surgical stress in neonates undergoing major surgery.
- To compare ICAM-1 levels between neonates with congenital diaphragmatic hernia and those undergoing gastrointestinal surgery.
Main Methods:
- Serum ICAM-1, C-reactive protein (CRP), and white blood cell (WBC) counts were measured in 15 neonates.
- Measurements were taken preoperatively and at multiple time points up to 120 hours post-surgery.
- Neonates were grouped based on surgical indication: congenital diaphragmatic hernia (Group I) or gastrointestinal surgery (Group II).
Main Results:
- ICAM-1 levels significantly increased within 24 hours post-surgery in both groups.
- ICAM-1 peaked at 72 hours in Group I and 96 hours in Group II.
- CRP levels rose post-surgery, while WBC counts showed no significant changes.
Conclusions:
- Neonatal surgical stress leads to increased serum ICAM-1 levels.
- Intestinal surgery may be associated with a more prolonged ICAM-1 response compared to non-intestinal surgery.
- ICAM-1 shows potential as a marker for endothelial damage and host response to surgical stress in neonates.