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Updated: Jul 15, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
14:28

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

HLA-binding peptides as a therapeutic approach for chronic HIV infection

A Sette1, R Chesnut, B Livingston

  • 1Epimmune Inc, 6555 Nacy Ridge Drive, Suite 100, San Diego, CA 92121, USA. asette@epimmune.com

Idrugs : the Investigational Drugs Journal
|August 13, 2005
PubMed

Herein, we describe the Epimmune approach to prophylaxis and development of a multi-epitope vaccine for immunotherapy of HIV-1 infection. The central strategy of our program is to induce cellular immune responses, cytotoxic T-lymphocytes (CTL) and helper Tlymphocytes (HTL), specific for conserved epitopes from both structural and regulatory proteins of HIV-1. The HIV-1 derived and HLA-restricted CTL and HTL epitopes needed to design and construct the experimental vaccines are now known and allow for broad and non-ethnically biased coverage of the human population. The design optimization of an epitope-based DNA vaccine and evaluating methods for various DNA vaccine delivery technologies for possible use in clinical trials are addressed.

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