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FDG uptake in colonic villous adenomas
Nuri Arslan1, Farrokh Dehdashti, Barry A Siegel
1Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA. narslan@gata.edu.tr
Annals of Nuclear Medicine
|August 16, 2005
Summary
Positron emission tomography (PET) scans can detect colonic villous adenomas, a precursor to colorectal cancer. This study found an 83.3% true-positive rate for these lesions, highlighting the need for further investigation of focal PET findings.
Area of Science:
- Gastroenterology
- Nuclear Medicine
- Oncology
Background:
- Colonic adenomas are common colorectal polyps with significant links to colorectal cancer.
- The diagnostic accuracy of fluorodeoxyglucose-positron emission tomography (FDG-PET) for colonic villous adenomas is not well-established.
- Not all colonic lesions identified by FDG-PET are malignant.
Purpose of the Study:
- To determine the rate of FDG-PET positivity in patients with colonic villous adenomas.
- To compare FDG-PET findings with pathological features of colonic villous adenomas.
Main Methods:
- A retrospective search of a pathology database identified patients diagnosed with colonic villous adenoma between June 1, 1996, and December 1, 2000.
- Included patients had a colonic villous adenoma diagnosis and an FDG-PET scan within one month prior to colonoscopy.
- FDG-PET findings were correlated with subsequent colonoscopic and pathological results.
Main Results:
- Out of over 4,000 patients, six met the inclusion criteria, with a total of 2 villous and 9 tubulovillous adenomas identified.
- Five of the six patients (83.3%) showed increased FDG uptake corresponding to their villous adenomas.
- FDG-PET detected the presence of these adenomas, indicating a significant true-positive rate.
Conclusions:
- Focal lesions detected by FDG-PET in the colon warrant further investigation, as they may represent villous adenomas.
- FDG-PET demonstrates potential in identifying colonic villous adenomas, though further studies are needed.
- Larger studies are required to correlate histopathological features with FDG-PET detectability of colonic polyps.