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Melatonin limits lung injury in bleomycin treated mice
Tiziana Genovese1, Rosanna Di Paola, Emanuela Mazzon
1Department Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina Torre Biologica, Policlinico Universitario, Messina, Italy.
Journal of Pineal Research
|August 16, 2005
Summary
Melatonin treatment significantly reduced lung injury in mice caused by bleomycin (BLM) administration. This protective effect involved decreased inflammation, edema, and mortality, highlighting melatonin
Area of Science:
- Immunology
- Pharmacology
- Toxicology
Background:
- Melatonin, a pineal gland hormone, modulates the immune system.
- Melatonin acts as an antioxidant, protecting against oxidative stress and inflammation.
- Bleomycin (BLM) induces significant lung injury.
Purpose of the Study:
- To investigate the protective effects of melatonin against bleomycin-induced lung injury in mice.
Main Methods:
- Mice received intratracheal bleomycin (BLM) to induce lung injury.
- Melatonin (10 mg/kg) was administered intraperitoneally daily.
- Lung injury was assessed by neutrophil infiltration (myeloperoxidase activity), edema, nitrotyrosine, poly-ADP-ribose (PAR) formation, body weight loss, and mortality.
Main Results:
- BLM administration caused significant lung injury, characterized by neutrophil infiltration, edema, increased nitrotyrosine and PAR, body weight loss, and mortality.
- Melatonin treatment significantly reduced body weight loss and mortality.
- Melatonin administration decreased neutrophil infiltration, edema, and nitrotyrosine/PAR formation, mitigating histological lung injury.
Conclusions:
- Melatonin demonstrates significant protective effects against bleomycin-induced lung injury in mice.
- Melatonin's antioxidant and anti-inflammatory properties contribute to its therapeutic potential in lung injury.
- These findings support melatonin as a potential therapeutic agent for lung injury.