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Related Experiment Videos

Thalamotomy versus thalamic stimulation for multiple sclerosis tremor.

Richard G Bittar1, Jonathan Hyam, Dipankar Nandi

  • 1Department of Neurosurgery, Radcliffe Infirmary, Oxford, UK. neurosurgeon@ampsclinic.com

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|August 16, 2005
PubMed
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Thalamotomy provided greater intention tremor reduction for multiple sclerosis (MS) patients than deep brain stimulation (DBS). However, DBS may be preferred due to fewer permanent neurological deficits.

Area of Science:

  • Neurosurgery
  • Neurology

Background:

  • Intractable tremor is a common and disabling symptom in multiple sclerosis (MS).
  • Current medical treatments are ineffective, and surgical outcomes are variable.
  • Thalamotomy and deep brain stimulation (DBS) are surgical options for MS tremor.

Purpose of the Study:

  • To compare the efficacy and adverse effects of thalamotomy versus thalamic DBS for intractable MS tremor.

Main Methods:

  • A study of twenty patients with intractable MS tremor.
  • Ten patients underwent thalamotomy, and ten received chronic thalamic DBS.
  • Outcomes including tremor improvement and adverse effects were assessed.

Main Results:

  • Both procedures improved postural and intention tremor.

Related Experiment Videos

  • Thalamotomy showed a greater improvement in intention tremor (72% vs. 36%, P < 0.05).
  • Thalamotomy had a higher incidence of permanent neurological deficits (30%) compared to DBS (10%).

    • Conclusions:

    • Thalamotomy is more efficacious for intention tremor reduction in MS.
    • Deep brain stimulation may be a preferred surgical strategy due to a lower risk of permanent deficits.