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Updated: Aug 16, 2026

In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells
Published on: July 23, 2010
Transcriptional regulation by human papillomaviruses
1Department of Microbiology & Immunology and the James P Wilmot Cancer Center, University of Rochester, Rochester, NY 14642, USA. dennis_mccance@urmc.rochester.edu
Abstract:
Human papillomaviruses are the causative agent of cancers in stratified epithelial surfaces. They replicate in the upper parts of the epithelium, where cells would normally be dying to produce a cornified layer. Therefore, they need to inhibit or delay differentiation and stimulate cell cycle progression to create an environment conducive for replication of the viral genome. The alterations both in differentiation and in the cell cycle are achieved by the viral proteins E6 and E7, which modulate cellular transcription mainly through their effects on p53 and the retinoblastoma family.
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