Related Experiment Video
Updated: Aug 16, 2026

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos
Published on: July 27, 2022
Organising cells into tissues: new roles for cell adhesion molecules in planar cell polarity
1Samuel Lunenfeld Research Institute, Toronto, Ontario M5G 1X, Canada.
Abstract:
Planar cell polarity (PCP) is the coordinated organization of cells within the plane of the epithelium, first described in Drosophila. A Frizzled signalling pathway dedicated to PCP (the non-canonical Frizzled pathway) acts through Dishevelled and small G proteins, as does the classical Wnt pathway, but then diverges downstream of Dishevelled. Recent studies have demonstrated a crucial role for several atypical cadherin molecules (Fat, Dachsous and Flamingo) in controlling PCP signalling. Recent work has also indicated that the first sign of PCP during development is the polarized localization of PCP proteins (Frizzled, Flamingo, Dishevelled, etc). Exciting new data reveal that this PCP pathway is conserved to man.
More Related Videos
12:15The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analysis and Imaging
Published on: October 3, 2017
15:41Improved Visualization and Quantitative Analysis of Drug Effects Using Micropatterned Cells
Published on: December 2, 2010
Related Concept Videos
Cell Adhesion in Plants
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose, and...
Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...
Cell Polarization by Rho Proteins
Cell Migration
Cell Migration
Cytoskeletal Coordination in Cell Migration