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Updated: Feb 25, 2026

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The Nemp1-Nesprin complex mediates cellular responses to matrix mechanics

Abira Ganguly1, Hannah Zmuda2, Javier Abello3

  • 1Department of Developmental Biology, Washington University, St. Louis, MO 63110.

Proceedings of the National Academy of Sciences of the United States of America
|February 23, 2026
PubMed
Summary

Softening the ovary rescues oocyte loss in NEMP1 knockout mice. Nuclear Envelope Membrane Protein 1 (NEMP1) regulates YAP mechanotransduction, crucial for fertility.

Keywords:
KASH domainNemp1YAP nuclear translocationcellular responses to mechanical stressnuclear mechanotransduction

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