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Massive hemoptysis in cystic fibrosis
Patrick A Flume1, James R Yankaskas, Myla Ebeling
1Department of Medicine, Medical University of South Carolina, 96 Jonathan Lucas St, 812-CSB, Charleston, SC 29425, USA. flumepa@musc.edu
Chest
|August 16, 2005
Summary
Massive hemoptysis is a serious complication for cystic fibrosis (CF) patients, particularly older individuals with advanced lung disease. This condition increases mortality, hospitalizations, and lung function decline in CF patients.
Area of Science:
- Pulmonary Medicine
- Genetics and Inherited Diseases
Background:
- Massive hemoptysis is a significant complication in cystic fibrosis (CF) patients.
- Understanding its pathophysiology and consequences is crucial for patient management.
Purpose of the Study:
- Identify risk factors for massive hemoptysis in CF patients.
- Determine the prognosis for CF patients following massive hemoptysis.
Main Methods:
- Retrospective, observational cohort study.
- Utilized data from the National CF Patient Registry (1990-1999).
- Included 28,858 CF patients across US centers.
Main Results:
- Annual incidence of massive hemoptysis was 0.87%; 4.1% overall.
- More prevalent in older patients with severe lung impairment (FEV1 < 40%).
- Risk factors included Staphylococcus aureus and diabetes; associated with increased morbidity and mortality.
Conclusions:
- Massive hemoptysis is a serious complication in CF, more common in older patients with advanced disease.
- Nearly 1% of CF patients experience this annually.
- Leads to increased mortality, healthcare utilization, and lung function decline.